Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

SLC7A6 (Q92536) - Overview - Molecular Target Synopsis


SLC7A6, Y+L amino acid transporter 2
UniProt Q92536

Also Known as YLAT2_HUMAN, SLC7A6, KIAA0245

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells. Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: SLC7A6 is active in the following subcellular-locations: basolateral cell membrane.
GO terms: SLC7A6 is active in the following subcellular-locations: basolateral plasma membrane, integral component of plasma membrane, intracellular membrane-bounded organelle, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project SLC7A6 has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: K_562, HS578T, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SiHa, C2BBe1, SW 620

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HeLa-S3, K562

(see details)

3D Structures

At greater than 50% identity similarity to SLC7A6 there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

SLC7A6 has been screened with compounds ( bioactivities). (see details)