Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC7A6 (Q92536) - Overview - Molecular Target Synopsis

Protein


SLC7A6, Y+L amino acid transporter 2
UniProt Q92536

Also Known as YLAT2_HUMAN, SLC7A6, KIAA0245

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells. Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLC7A6 is active in the following subcellular-locations: basolateral cell membrane.
GO terms: SLC7A6 is active in the following subcellular-locations: basolateral plasma membrane, integral component of plasma membrane, intracellular membrane-bounded organelle, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC7A6 has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, HS578T, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SiHa, C2BBe1, SW 620

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HeLa-S3, K562

(see details)

3D Structures


At greater than 50% identity similarity to SLC7A6 there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SLC7A6 has been screened with compounds ( bioactivities). (see details)