Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TRIB2 (Q92519) - Overview - Molecular Target Synopsis

Protein


TRIB2, Tribbles homolog 2
UniProt Q92519

Also Known as TRIB2_HUMAN, TRIB2, TRB2

Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity. Interacts with COP1 (PubMed:27041596).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TRIB2 is active in the following subcellular-locations: cytoplasm, cytoskeleton.
GO terms: TRIB2 is active in the following subcellular-locations: cytoplasm, cytoskeleton, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TRIB2 has gain in 6 cell-lines, loss in 1 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_28, UACC_257, UACC_62

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: CHP-212, SK-N-FI, WM-115

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, NHLF

(see details)

RNA Interference


TRIB2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: TOV112D, CAL120. (see details)

3D Structures


At greater than 50% identity similarity to TRIB2 there are:
3 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TRIB2 has been screened with compounds ( bioactivities). (see details)