Molecular Target Synopsis
Overview
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Adarb1 (Q91ZS8) - Overview - Molecular Target Synopsis

Protein


Adarb1, Double-stranded RNA-specific editase 1
Enzyme Classification 3.5.4.37
UniProt Q91ZS8

Also Known as RED1_MOUSE, Adarb1, Adar2, Red1

Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can inhibit cell proliferation and migration and can stimulate exocytosis. Homodimer. Homodimerization is essential for its catalytic activity. Can form heterodimers with isoform 5 of ADAR/ADAR1 (By similarity).

2L2K
SOLUTION NMR STRUCTURE OF THE R/G STEM LOOP RNA-ADAR2 DSRBM2 COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for Adarb1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
760Q91ZS8-6
711Q91ZS8-1
701Q91ZS8-2
695Q91ZS8-3
687Q91ZS8-4
677Q91ZS8-5

Sub-cellular localization


UniProt: Adarb1 is active in the following subcellular-locations: nucleolus, nucleus.
GO terms: Adarb1 is active in the following subcellular-locations: cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Adarb1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Adarb1 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis