Molecular Target Synopsis
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S (Q91AV1) - Overview - Molecular Target Synopsis

Protein


S, Spike glycoprotein
UniProt Q91AV1

Also Known as SPIKE_PEDV7, S

S1 region attaches the virion to the cell membrane by interacting with host ANPEP/aminopeptidase N, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Homotrimer. During virus morphogenesis, found in a complex with M and HE proteins. Interacts with host ANPEP.

4J79
6 RESIDUE FRAGMENT OF
SPIKE GLYCOPROTEIN
IN THE STRUCTURE OF
CRYSTAL STRUCTURE OF BETA'-COP/PEDVSPIKE COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for S

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1383Q91AV1-1

Sub-cellular localization


UniProt: S is active in the following subcellular-locations: host endoplasmic reticulum-golgi intermediate compartment membrane, virion membrane.
GO terms: S is active in the following subcellular-locations: host cell endoplasmic reticulum-Golgi intermediate compartment membrane, integral component of membrane, viral envelope, virion membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project S has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For S there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis