Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

acs (Q8ZKF6) - Overview - Molecular Target Synopsis

Protein


acs, Acetyl-coenzyme A synthetase
Enzyme Classification 6.2.1.1
UniProt Q8ZKF6

Also Known as ACSA_SALTY, acs

Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA., Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt. Acetylates CheY, the response regulator involved in flagellar movement and chemotaxis. Monomer.

5JRH
CRYSTAL STRUCTURE OF SALMONELLA ENTERICA ACETYL-COA SYNTHETASE (ACS) IN COMPLEX WITH CAMP AND COENZYME A
RCSB/PDB
Inspect Structure
See all 3D Structures for acs

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
652Q8ZKF6-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project acs has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For acs there are:
9 structures (18 chains) solved
9 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

acs is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (2P2F_A, 2P2F_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


acs has been screened with compounds ( bioactivities). (see details)