Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TTN (Q8WZ42) - Overview - Molecular Target Synopsis

Protein


TTN, Titin
Enzyme Classification 2.7.11.1
UniProt Q8WZ42

Also Known as TITIN_HUMAN, TTN

Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. Interacts with MYOM1, MYOM2, tropomyosin and myosin. Interacts with actin, primarily via the PEVK domains and with MYPN (By similarity). Interacts with FHL2, NEB, CRYAB, LMNA/lamin-A and LMNB/lamin-B. Interacts with TCAP/telethonin and/or ANK1 isoform Mu17/ank1.5, via the first two N-terminal immunoglobulin domains. Interacts with TRIM63 and TRIM55, through several domains including immunoglobulin domains 141 and 142. Interacts with ANKRD1, ANKRD2 and ANKRD23, via the region between immunoglobulin domains 77 and 78 and interacts with CAPN3, via immunoglobulin domain 79. Interacts with NBR1 through the protein kinase domain. Interacts with CALM/calmodulin. Isoform 6 interacts with OBSCN isoform 3. Interacts with CMYA5.

6FWX
CHIMERIC TITIN Z1Z2-Z1Z2 TANDEM (Z1212) FUNCTIONALIZED WITH A GRGDS EXOGENOUS PEPTIDE FROM FIBRONECTIN
RCSB/PDB
Inspect Structure
See all 3D Structures for TTN

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TTN is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: TTN is active in the following subcellular-locations: condensed nuclear chromosome, cytosol, extracellular exosome, extracellular region, I band, M band, sarcomere, striated muscle thin filament, Z disc.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TTN has gain in 4 cell-lines, loss in 1 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: PC_3, TK_10, K_562

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, HCC12

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: GM12878, SK-N-SH, NHLF

(see details)

3D Structures


For TTN there are:
41 structures (118 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TTN has been screened with compounds ( bioactivities). (see details)