Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LRTOMT (Q8WZ04) - Overview - Molecular Target Synopsis

Protein


LRTOMT, Transmembrane O-methyltransferase
Enzyme Classification 2.1.1.6
UniProt Q8WZ04

Also Known as TOMT_HUMAN, LRTOMT, COMT2, TOMT

Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function (PubMed:18794526). Component of the cochlear hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity. Interacts with LHFPL5, PCDH15, TMC1, TMC2 and TMIE. Interacts directly with TMC1. The interaction of TOMT with TMC1 and TMC2 is required for the transportation of TMC1/2 into the stereocilia of hair cells.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: LRTOMT is active in the following subcellular-locations: cytoplasm, endoplasmic reticulum, membrane.
GO terms: LRTOMT is active in the following subcellular-locations: endoplasmic reticulum, integral component of membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LRTOMT has gain in 13 cell-lines, loss in 0 cell-lines and no signal in 992 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, T47D, OVCAR_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC33, HCC1500, CPC-N

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to LRTOMT there are:
112 structures (175 chains) solved
102 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

LRTOMT is solved in complex with the approved drug(s):

TCW/TOLCAPONE (3S68_A, 4PYL_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


LRTOMT has been screened with compounds ( bioactivities). (see details)