RIN2 (Q8WYP3) - Overview - Molecular Target Synopsis
RIN2, Ras and Rab interactor 2
Also Known as RIN2_HUMAN, RIN2, RASSF4
Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP. Homotetramer; probably composed of anti-parallel linkage of two parallel dimers. Interacts with Ras. Interacts with RAB5B, with a much higher affinity for GTP-bound activated RAB5B. Does not interact with other members of the Rab family.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
UniProt: RIN2 is active in the following subcellular-locations: cytoplasm.
GO terms: RIN2 is active in the following subcellular-locations: cytosol.