Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CTNNBL1 (Q8WYA6) - Overview - Molecular Target Synopsis

Protein


CTNNBL1, Beta-catenin-like protein 1
UniProt Q8WYA6

Also Known as CTBL1_HUMAN, CTNNBL1, C20orf33

Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis. Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly with CWC15 and CDC5L in the complex. Interacts with AICDA; the interaction is important for the antibody diversification activity of AICDA. Interacts with PRPF31 (via its NLS). Interacts (via its N-terminal NLS) with KPNA1 and KPNA2.

4MFV
CRYSTAL STRUCTURE OF HUMAN CTNNBL1(RESIDUES 33~563)
RCSB/PDB
Inspect Structure
See all 3D Structures for CTNNBL1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: CTNNBL1 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: CTNNBL1 is active in the following subcellular-locations: cytoplasm, membrane, nucleoplasm, nucleus, Prp19 complex, spliceosomal complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CTNNBL1 has gain in 8 cell-lines, loss in 0 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H322M, CCRF_CEM, MOLT_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H322T, SET-2, MOLM-16

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For CTNNBL1 there are:
7 structures (8 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis