Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

SLC7A3 (Q8WY07) - Overview - Molecular Target Synopsis


SLC7A3, Cationic amino acid transporter 3
UniProt Q8WY07

Also Known as CTR3_HUMAN, SLC7A3, ATRC3, CAT3

Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
619ENSG00000165349ENST00000374299, ENST00000298085ENSP00000363417, ENSP00000298085Q8WY07-1

Sub-cellular localization

UniProt: SLC7A3 is active in the following subcellular-locations: cell membrane.
GO terms: SLC7A3 is active in the following subcellular-locations: integral component of membrane, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project SLC7A3 has gain in 0 cell-lines, loss in 29 cell-lines and no signal in 976 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: CCRF_CEM, MOLT_4, MDA_MB_435

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NTERA-2, Daudi, MHH-PREB-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: H1-hESC, SK-N-SH, NHLF

(see details)

3D Structures

At greater than 35% identity similarity to SLC7A3 there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

SLC7A3 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

SLC7A3 has been screened with compounds ( bioactivities). (see details)