Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC7A3 (Q8WY07) - Overview - Molecular Target Synopsis

Protein


SLC7A3, Cationic amino acid transporter 3
UniProt Q8WY07

Also Known as CTR3_HUMAN, SLC7A3, ATRC3, CAT3

Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
619ENSG00000165349ENST00000374299, ENST00000298085ENSP00000363417, ENSP00000298085Q8WY07-1

Sub-cellular localization


UniProt: SLC7A3 is active in the following subcellular-locations: cell membrane.
GO terms: SLC7A3 is active in the following subcellular-locations: integral component of membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC7A3 has gain in 0 cell-lines, loss in 29 cell-lines and no signal in 976 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: CCRF_CEM, MOLT_4, MDA_MB_435

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NTERA-2, Daudi, MHH-PREB-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: H1-hESC, SK-N-SH, NHLF

(see details)

3D Structures


At greater than 35% identity similarity to SLC7A3 there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

SLC7A3 is solved in complex with the approved drug(s):

CLR/CHOLESTEROL (6F34_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SLC7A3 has been screened with compounds ( bioactivities). (see details)