Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB40A (Q8WXH6) - Overview - Molecular Target Synopsis

Protein


RAB40A, Ras-related protein Rab-40A
UniProt Q8WXH6

Also Known as RB40A_HUMAN, RAB40A

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
339ENSG00000172476ENST00000372633ENSP00000361716
306ENSG00000172476ENST00000304236ENSP00000305648
277Q8WXH6-1

Sub-cellular localization


UniProt: RAB40A is active in the following subcellular-locations: cell membrane.
GO terms: RAB40A is active in the following subcellular-locations: Golgi membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB40A has gain in 2 cell-lines, loss in 31 cell-lines and no signal in 971 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, NCI_ADR_RES, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, HCC12

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HMEC

(see details)

3D Structures


At greater than 35% identity similarity to RAB40A there are:
101 structures (210 chains) solved
90 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

RAB40A is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (3NKV_A, 3NKV_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB40A has been screened with compounds ( bioactivities). (see details)