Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HTR3C (Q8WXA8) - Overview - Molecular Target Synopsis

Protein


HTR3C, 5-hydroxytryptamine receptor 3C
UniProt Q8WXA8

Also Known as 5HT3C_HUMAN, HTR3C

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
447ENSG00000178084ENST00000318351ENSP00000322617Q8WXA8-1

Sub-cellular localization


UniProt: HTR3C is active in the following subcellular-locations: cell membrane.
GO terms: HTR3C is active in the following subcellular-locations: integral component of plasma membrane, neuron projection, plasma membrane, synapse.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project HTR3C has gain in 10 cell-lines, loss in 1 cell-lines and no signal in 993 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OvCA 429, OVCAR433, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)


Screening and Chemistry


HTR3C has been screened with 480 compounds (667 bioactivities), 218 compounds have bioactivities that show binding affinity of <= 500nM (288 bioactivities). (see details)