Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

HTR3C (Q8WXA8) - Overview - Molecular Target Synopsis


HTR3C, 5-hydroxytryptamine receptor 3C
UniProt Q8WXA8

Also Known as 5HT3C_HUMAN, HTR3C

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: HTR3C is active in the following subcellular-locations: cell membrane.
GO terms: HTR3C is active in the following subcellular-locations: integral component of plasma membrane, neuron projection, plasma membrane, synapse.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project HTR3C has gain in 10 cell-lines, loss in 1 cell-lines and no signal in 993 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OvCA 429, OVCAR433, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

Screening and Chemistry

HTR3C has been screened with 480 compounds (667 bioactivities), 218 compounds have bioactivities that show binding affinity of <= 500nM (288 bioactivities). (see details)