Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCA5 (Q8WWZ7) - Overview - Molecular Target Synopsis

Protein


ABCA5, ATP-binding cassette sub-family A member 5
UniProt Q8WWZ7

Also Known as ABCA5_HUMAN, ABCA5, KIAA1888

May play a role in the processing of autolysosomes.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABCA5 is active in the following subcellular-locations: golgi apparatus membrane, late endosome membrane, lysosome membrane.
GO terms: ABCA5 is active in the following subcellular-locations: Golgi apparatus, Golgi membrane, integral component of membrane, intracellular membrane-bounded organelle, late endosome, late endosome membrane, lysosomal membrane, lysosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCA5 has gain in 5 cell-lines, loss in 0 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: M14, SK_MEL_28, SK_MEL_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: CPC-N, HCC33, NCI-H82

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: MCF-7, HFDPC, SK-N-SH

(see details)

3D Structures


At greater than 35% identity similarity to ABCA5 there are:
2 structures (3 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ABCA5 has been screened with compounds ( bioactivities). (see details)