Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCA10 (Q8WWZ4) - Overview - Molecular Target Synopsis

Protein


ABCA10, ATP-binding cassette sub-family A member 10
UniProt Q8WWZ4

Also Known as ABCAA_HUMAN, ABCA10

Probable transporter which may play a role in macrophage lipid homeostasis.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABCA10 is active in the following subcellular-locations: membrane.
GO terms: ABCA10 is active in the following subcellular-locations: integral component of membrane, intracellular membrane-bounded organelle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCA10 has gain in 4 cell-lines, loss in 0 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: TK_10, KM12, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: BICR 31, BHY, PK-45P

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to ABCA10 there are:
2 structures (3 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ABCA10 has been screened with compounds ( bioactivities). (see details)