Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LIPH (Q8WWY8) - Overview - Molecular Target Synopsis

Protein


LIPH, Lipase member H
Enzyme Classification 3.1.1.-
UniProt Q8WWY8

Also Known as LIPH_HUMAN, LIPH, LPDLR, MPAPLA1, PLA1B

Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: LIPH is active in the following subcellular-locations: membrane, secreted.
GO terms: LIPH is active in the following subcellular-locations: extracellular space, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LIPH has gain in 10 cell-lines, loss in 1 cell-lines and no signal in 994 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H322M, HCC_2998, OVCAR_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Calu-3, OCUM-1, ABC-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to LIPH there are:
12 structures (21 chains) solved
9 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


LIPH has been screened with compounds ( bioactivities). (see details)