Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CANT1 (Q8WVQ1) - Overview - Molecular Target Synopsis

Protein


CANT1, Soluble calcium-activated nucleotidase 1
Enzyme Classification 3.6.1.6
UniProt Q8WVQ1

Also Known as CANT1_HUMAN, CANT1, SHAPY

Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP (PubMed:12234496, PubMed:15248776, PubMed:15006348, PubMed:16835225). Involved in proteoglycan synthesis (PubMed:22539336). Monomer (PubMed:12234496, PubMed:15006348). Homodimer; dimerization is Ca(2+)-dependent (PubMed:16835225). Homodimer; disulfide-linked (membrane form) (PubMed:16835225).

2H2U
CRYSTAL STRUCTURE OF THE E130Y MUTANT OF HUMAN SOLUBLE CALCIUM- ACTIVATED NUCLEOTIDASE (SCAN) WITH CALCIUM ION
RCSB/PDB
Inspect Structure
See all 3D Structures for CANT1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: CANT1 is active in the following subcellular-locations: cell membrane, endoplasmic reticulum membrane, golgi apparatus, golgi stack membrane.
GO terms: CANT1 is active in the following subcellular-locations: endoplasmic reticulum membrane, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, Golgi cisterna membrane, integral component of membrane, membrane, plasma membrane, specific granule lumen, tertiary granule lumen.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CANT1 has gain in 4 cell-lines, loss in 0 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: T47D, COLO205, LOXIMVI

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCUM-1, HM7, SNU-719

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, A549

(see details)

3D Structures


For CANT1 there are:
4 structures (8 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CANT1 has been screened with compounds ( bioactivities). (see details)