Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LMBR1 (Q8WVP7) - Overview - Molecular Target Synopsis

Protein


LMBR1, Limb region 1 protein homolog
UniProt Q8WVP7

Also Known as LMBR1_HUMAN, LMBR1, C7orf2, DIF14

Putative membrane receptor.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: LMBR1 is active in the following subcellular-locations: membrane.
GO terms: LMBR1 is active in the following subcellular-locations: integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LMBR1 has gain in 3 cell-lines, loss in 4 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, SR, OVCAR_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MCF-7, SNU-719, CL-11

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, MCF-7, K562

(see details)

RNA Interference


LMBR1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: RMGI, CROE33. (see details)