Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TFB1M (Q8WVM0) - Overview - Molecular Target Synopsis

Protein


TFB1M, Dimethyladenosine transferase 1, mitochondrial
Enzyme Classification 2.1.1.-
UniProt Q8WVM0

Also Known as TFB1M_HUMAN, TFB1M

S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.

6AJK
CRYSTAL STRUCTURE OF TFB1M AND H45 IN HOMO SAPIENS
RCSB/PDB
Inspect Structure
See all 3D Structures for TFB1M

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
346ENSG00000029639ENST00000367166ENSP00000356134Q8WVM0-1

Sub-cellular localization


UniProt: TFB1M is active in the following subcellular-locations: mitochondrion.
GO terms: TFB1M is active in the following subcellular-locations: mitochondrial matrix, mitochondrial nucleoid.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TFB1M has gain in 0 cell-lines, loss in 3 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SW_620, SK_MEL_28, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hep G2, A-375, C3A

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HMEC, K562

(see details)

3D Structures


For TFB1M there are:
2 structures (3 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis