Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

TFB1M (Q8WVM0) - Overview - Molecular Target Synopsis


TFB1M, Dimethyladenosine transferase 1, mitochondrial
Enzyme Classification 2.1.1.-
UniProt Q8WVM0

Also Known as TFB1M_HUMAN, TFB1M

S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: TFB1M is active in the following subcellular-locations: mitochondrion.
GO terms: TFB1M is active in the following subcellular-locations: mitochondrial matrix, mitochondrial nucleoid.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project TFB1M has gain in 0 cell-lines, loss in 3 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SW_620, SK_MEL_28, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hep G2, A-375, C3A

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HMEC, K562

(see details)

3D Structures

At greater than 75% identity similarity to TFB1M there are:
2 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis