Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

EEF1AKMT1 (Q8WVE0) - Overview - Molecular Target Synopsis

Protein


EEF1AKMT1, EEF1A lysine methyltransferase 1
Enzyme Classification 2.1.1.-
UniProt Q8WVE0

Also Known as EFMT1_HUMAN, EEF1AKMT1, N6AMT2

Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
214ENSG00000150456ENST00000382754, ENST00000382758ENSP00000372202, ENSP00000372206Q8WVE0-1

Sub-cellular localization


UniProt: EEF1AKMT1 is active in the following subcellular-locations: cytoplasm.
GO terms: EEF1AKMT1 is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project EEF1AKMT1 has gain in 3 cell-lines, loss in 4 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are:

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are:

(see details)