Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SNX33 (Q8WV41) - Overview - Molecular Target Synopsis

Protein


SNX33, Sorting nexin-33
UniProt Q8WV41

Also Known as SNX33_HUMAN, SNX33, SH3PX3, SH3PXD3C, SNX30

Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes. Homodimer (via BAR domain). Interacts with ADAM15. Interacts with FASLG. Interacts (via SH3 domain) with DNM1 and DNM2. Interacts with WASL. Interacts with FCHSD1 (via the F-BAR domain).

4AKV
CRYSTAL STRUCTURE OF HUMAN SORTING NEXIN 33 (SNX33)
RCSB/PDB
Inspect Structure
See all 3D Structures for SNX33

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
574ENSG00000173548ENST00000308527ENSP00000311427Q8WV41-1
279ENSG00000173548ENST00000569152ENSP00000455436

Sub-cellular localization


UniProt: SNX33 is active in the following subcellular-locations: cytoplasm, cytoplasmic vesicle membrane, cytosol, membrane.
GO terms: SNX33 is active in the following subcellular-locations: cytoplasmic vesicle, cytoplasmic vesicle membrane, cytosol, extrinsic component of membrane, membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SNX33 has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H226, MALME_3M, HT29

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCUM-1, HCC364, BHY

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HMEC, BJ

(see details)

3D Structures


For SNX33 there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis