Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations

HDAC7 (Q8WUI4) - Overview - Molecular Target Synopsis

Protein


HDAC7, Histone deacetylase 7
Enzyme Classification 3.5.1.98
UniProt Q8WUI4

Also Known as HDAC7_HUMAN, HDAC7, HDAC7A

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Interacts with HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, NCOR1, NCOR2, SIN3A, SIN3B, RBBP4, RBBP7, MTA1L1, SAP30 and MBD3. Interacts with the 14-3-3 protein YWHAE, MEF2A, MEF2B and MEF2C (By similarity). Interacts with KAT5 and EDNRA. Interacts with KDM5B. Interacts with ZMYND15 (By similarity). Interacts with PML (isoform PML-4). Interacts with FOXP3.

3ZNS deposition date (15-FEB-13)
HDAC7 BOUND WITH TFMO INHIBITOR TMP942
RCSB/PDB
Inspect Structure
See all 3D Structures for HDAC7

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: HDAC7 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: HDAC7 is active in the following subcellular-locations: cytoplasm, cytosol, histone deacetylase complex, nucleoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project HDAC7 has gain in 7 cell-lines, loss in 0 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: OVCAR_3, SK_OV_3, OVCAR_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NIH:OVCAR-3, OVKATE, COV362

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, HUVEC

(see details)

RNA Interference


HDAC7 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

3D Structures


There are 5 structures (15 chains) solved for HDAC7
4 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

HDAC7 is solved in complex with the approved drug(s):

SHH/ (1C3S_A, 1T69_A, 1ZZ1_A, 1ZZ1_B, 1ZZ1_C, 1ZZ1_D, 3C0Z_A, 3C0Z_B, 3C0Z_C, 4LXZ_A, 4LXZ_B, 4LXZ_C, 4QA0_A, 4QA0_B, 4QA2_A, 4QA2_B, 5EEI_A, 5EEI_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


HDAC7 has been screened with 2710 compounds (4382 bioactivities), 969 compounds have bioactivities that show binding affinity of <= 500nM (1197 bioactivities). (see details)