Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB2B (Q8WUD1) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 08/10/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 08/10/2019)


Chains assessed1
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria1


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2A5J_A Ras-related protein Rab-2B Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.14 69.9 27 Yes No
2 empty 2.3 71.9 25.8 No No
3 empty 2.32 67.1 17.5 No No
4 empty 2 64.6 16.8 No No
5 empty 2.57 60.7 21 No No
6 empty 2.61 73.6 10.8 No No
7 empty 2.55 47.3 11.3 No No
8 empty 2.07 61.7 10.1 No No
9 empty 2.49 61.1 13.2 No No
10 empty 2.16 74.1 7.8 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed1
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria1

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2A5J_A (126175) Ras-related protein Rab-2B P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins 1.5Å Yes No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


RAB2B is involved in 9 interactions in the network.


Druggability
Overall Druggability Percentile: 10.03
Druggability for Cancer Therapeutics: 53.37
Druggability for Other Therapeutics: 23.40
Cancer-Associated
Cancer-associated percentile : 65.88
Network Articulation Point
Is RAB2B critical for communication in the network?


Detailed Graph Legend:Help