Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB2B (Q8WUD1) - Overview - Molecular Target Synopsis

Protein


RAB2B, Ras-related protein Rab-2B
UniProt Q8WUD1

Also Known as RAB2B_HUMAN, RAB2B

Required for protein transport from the endoplasmic reticulum to the Golgi complex.

2A5J
CRYSTAL STRUCTURE OF HUMAN RAB2B
RCSB/PDB
Inspect Structure
See all 3D Structures for RAB2B

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
216ENSG00000129472ENST00000397762ENSP00000380869Q8WUD1-1
151Q8WUD1-2
62ENSG00000129472ENST00000417141ENSP00000405441

Sub-cellular localization


UniProt: RAB2B is active in the following subcellular-locations: cell membrane, endoplasmic reticulum membrane, golgi apparatus membrane.
GO terms: RAB2B is active in the following subcellular-locations: endoplasmic reticulum membrane, extracellular exosome, Golgi membrane, plasma membrane, presynapse.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB2B has gain in 5 cell-lines, loss in 1 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: DU_145, SK_MEL_2, NCI_H522

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DMS 79, SK-N-FI, NCI-H2171

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HUVEC

(see details)

3D Structures


For RAB2B there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB2B has been screened with compounds ( bioactivities). (see details)