MZB1 (Q8WU39) - Overview - Molecular Target Synopsis
MZB1, Marginal zone B- and B1-cell-specific protein
Also Known as MZB1_HUMAN, MZB1, MEDA7, PACAP
Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation., Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance. Part of the ER chaperone complex, a multi-protein complex in the endoplasmic reticulum containing a large number of molecular chaperones which associates with unassembled incompletely folded immunoglobulin heavy chains (By similarity). Isoform 2 interacts with CASP2 and CASP9. Interacts with HSP90B1 and PDIA3 in a calcium-dependent manner.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|75||ENSG00000170476||ENST00000417694, ENST00000457570||ENSP00000415420, ENSP00000406529||Q8WU39-4|
UniProt: MZB1 is active in the following subcellular-locations: cytoplasm, endoplasmic reticulum lumen, secreted.
GO terms: MZB1 is active in the following subcellular-locations: cytoplasm, endoplasmic reticulum chaperone complex, endoplasmic reticulum lumen, extracellular region.