Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

MZB1 (Q8WU39) - Overview - Molecular Target Synopsis


MZB1, Marginal zone B- and B1-cell-specific protein
UniProt Q8WU39

Also Known as MZB1_HUMAN, MZB1, MEDA7, PACAP

Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation., Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance. Part of the ER chaperone complex, a multi-protein complex in the endoplasmic reticulum containing a large number of molecular chaperones which associates with unassembled incompletely folded immunoglobulin heavy chains (By similarity). Isoform 2 interacts with CASP2 and CASP9. Interacts with HSP90B1 and PDIA3 in a calcium-dependent manner.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: MZB1 is active in the following subcellular-locations: cytoplasm, endoplasmic reticulum lumen, secreted.
GO terms: MZB1 is active in the following subcellular-locations: cytoplasm, endoplasmic reticulum chaperone complex, endoplasmic reticulum lumen, extracellular region.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project MZB1 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KMS-21BM, KARPAS-620, SK-MM-2

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: GM12878, CD20-positive B cell, CD34-positive mobilized cell

(see details)

Screening and Chemistry

MZB1 has been screened with compounds ( bioactivities). (see details)