Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MZB1 (Q8WU39) - Overview - Molecular Target Synopsis

Protein


MZB1, Marginal zone B- and B1-cell-specific protein
UniProt Q8WU39

Also Known as MZB1_HUMAN, MZB1, MEDA7, PACAP

Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation., Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance. Part of the ER chaperone complex, a multi-protein complex in the endoplasmic reticulum containing a large number of molecular chaperones which associates with unassembled incompletely folded immunoglobulin heavy chains (By similarity). Isoform 2 interacts with CASP2 and CASP9. Interacts with HSP90B1 and PDIA3 in a calcium-dependent manner.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MZB1 is active in the following subcellular-locations: cytoplasm, endoplasmic reticulum lumen, secreted.
GO terms: MZB1 is active in the following subcellular-locations: cytoplasm, endoplasmic reticulum chaperone complex, endoplasmic reticulum lumen, extracellular region.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MZB1 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KMS-21BM, KARPAS-620, SK-MM-2

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: GM12878, CD20-positive B cell, CD34-positive mobilized cell

(see details)


Screening and Chemistry


MZB1 has been screened with compounds ( bioactivities). (see details)