Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

STK32A (Q8WU08) - Overview - Molecular Target Synopsis

Protein


STK32A, Serine/threonine-protein kinase 32A
Enzyme Classification 2.7.11.1
UniProt Q8WU08

Also Known as ST32A_HUMAN, STK32A, YANK1


4FR4
CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE-PROTEIN KINASE 32A (YANK1)
RCSB/PDB
Inspect Structure
See all 3D Structures for STK32A

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: STK32A is active in the following subcellular-locations: cell membrane.
GO terms: STK32A is active in the following subcellular-locations: plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project STK32A has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H209, NCI-H345, COLO 792

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


STK32A was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: RMGI, TOV112D. (see details)

3D Structures


For STK32A there are:
1 structures (6 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


STK32A has been screened with 77 compounds (77 bioactivities), 2 compounds have bioactivities that show binding affinity of <= 500nM (2 bioactivities). (see details)