Molecular Target Synopsis
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cinA (Q8VQF6) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed20
Chains with at least one site assessed as druggable using the strict criteria5
Chains with at least one site assessed as druggable using the relaxed criteria20


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
1T2B_B 1,8-cineole 2-endo-monooxygenase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.92 66.2 34.4 Yes No
2 empty 2.35 66.3 37 No No
3 empty 2.05 67.2 26.3 No No
4 empty 2.06 66.9 24 No No
5 empty 2.39 67.6 27.7 No No
6 empty 2.44 62.2 18.9 No No
7 empty 2.15 68.7 13.5 No No
8 empty 2.25 60.9 22.4 No No
9 empty 2.27 62.1 17.3 No No
10 empty 1.76 69.6 15.5 No No
3BDZ_A 1,8-cineole 2-endo-monooxygenase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 67.2 47.4 Yes Yes
2 empty 2.39 66.9 36 No No
3 empty 2 66.4 27.5 No No
4 empty 2.53 63.8 25.5 No No
5 bound 1.71 99.4 0 Yes No
6 empty 1.77 68 16.7 No No
7 empty 2.11 67.4 20.1 No No
8 empty 1.95 69.3 13.4 No No
9 empty 1.78 55.4 12.8 No No
10 empty 1.84 74.5 10.2 No No
4FMX_A 1,8-cineole 2-endo-monooxygenase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.11 67.2 32.5 Yes No
2 bound 2.37 66.8 36.9 No No
3 empty 2.01 70.8 25.7 No No
4 empty 1.93 66.9 20 No No
5 empty 2.59 69.8 15 No No
6 empty 2.45 63.7 20.4 No No
7 empty 2.45 76.6 12.6 No No
8 empty 2.22 67.2 20.4 No No
9 empty 1.74 73.2 12.9 No No
10 empty 2.31 66.9 14.8 No No
4L6G_B 1,8-cineole 2-endo-monooxygenase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 69.8 33.3 Yes No
2 empty 2.33 65.1 36.3 No No
3 empty 2.37 66.9 29.2 No No
4 empty 1.91 69.1 25.4 No No
5 empty 1.9 66.8 17 No No
6 empty 2.45 63 19 No No
7 bound 1.81 68.1 13.9 No No
8 empty 2.32 66.5 12.5 No No
9 empty 2.42 68.3 11.1 No No
10 empty 1.82 54.4 12.9 No No
4L77_B 1,8-cineole 2-endo-monooxygenase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.01 69 32.1 Yes No
2 empty 2.33 65.3 38.3 No No
3 empty 2.19 68.1 33.9 No No
4 empty 2.06 70 24.7 No No
5 empty 2.46 65.8 24.3 No No
6 empty 2.02 66 25.9 No No
7 empty 2.4 64.9 21.4 No No
8 bound 1.35 99.3 0 Yes No
9 empty 1.83 54.4 12.3 No No
10 empty 2.41 62.4 14.6 No No
4LHT_B 1,8-cineole 2-endo-monooxygenase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.37 66.2 33.9 Yes No
2 empty 2.02 69.5 30.6 No No
3 empty 2.14 64.8 25.2 No No
4 empty 1.89 72.8 26.6 No No
5 empty 2.27 66.8 23.4 No No
6 empty 1.82 68.8 14.5 No No
7 empty 2.38 67 22.8 No No
8 empty 2.03 67 11.4 No No
9 empty 1.79 56.4 12.2 No No
10 bound 1.74 100 0 Yes No
4FB2_A 1,8-cineole 2-endo-monooxygenase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.8 69.7 54.1 Yes Yes
2 bound 2.48 67.8 30.5 No No
3 empty 2.1 68.6 13.6 No No
4 empty 2.14 61.5 15.7 No No
5 empty 2.11 72.2 13.7 No No
6 empty 1.99 75.1 15.7 No No
7 empty 1.75 67.9 12.7 No No
8 empty 1.54 59 17.5 No No
9 empty 2.03 64.8 12.5 No No
10 empty 2.3 61.5 14.2 No No
1T2B_A 1,8-cineole 2-endo-monooxygenase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 66 27.4 Yes No
2 empty 2.32 65.1 37 No No
3 empty 1.89 72.3 21.9 No No
4 empty 1.93 64.4 25.4 No No
5 empty 2.39 67.1 24.6 No No
6 empty 1.92 69.2 16.5 No No
7 empty 2.14 69.1 11.4 No No
8 empty 2.2 71.8 16.4 No No
9 empty 2.08 59.1 16.1 No No
10 bound 1.62 100 0 Yes No
4FYZ_A 1,8-cineole 2-endo-monooxygenase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.91 68.8 34.3 Yes No
2 empty 2.37 63.2 36.7 No No
3 empty 2.24 66.4 28.1 No No
4 empty 1.94 71.3 24.1 No No
5 empty 2.06 63.9 22.5 No No
6 empty 1.85 68.4 13.8 No No
7 empty 2.27 63 16.4 No No
8 bound 1.56 99.6 0 Yes No
9 empty 1.67 69.9 9.5 No No
10 empty 1.97 62.1 12.4 No No
4FYZ_B 1,8-cineole 2-endo-monooxygenase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 69.4 33.8 Yes No
2 empty 2.32 65.4 37.1 No No
3 empty 1.98 68.3 26.1 No No
4 empty 2.02 67.2 20.3 No No
5 empty 2.37 72.3 13.7 No No
6 empty 2.62 65.1 15.2 No No
7 empty 2.08 64.2 15.5 No No
8 empty 2.05 64.4 17 No No
9 bound 1.77 99.6 0 Yes No
10 empty 1.97 79.5 10.5 No No
3BE0_B 1,8-cineole 2-endo-monooxygenase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.78 71 45.6 Yes No
2 empty 2.42 68.2 33 No No
3 empty 2.16 66.7 27 No No
4 empty 1.97 69.8 26.4 No No
5 empty 2.35 69.5 21.3 No No
6 empty 2.39 64.7 25 No No
7 empty 2.04 70.5 13.9 No No
8 bound 1.64 99 0 Yes No
9 empty 2.36 64.5 14.8 No No
10 empty 1.93 75.3 13.4 No No
4L77_A 1,8-cineole 2-endo-monooxygenase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 66.9 38.5 Yes No
2 empty 2.04 68.2 31 No No
3 empty 2.42 64.8 28.5 No No
4 empty 2.16 66.7 22.8 No No
5 empty 2.18 61.3 26.6 No No
6 empty 2.28 67.2 17.9 No No
7 empty 2.18 67.4 20.2 No No
8 bound 1.32 100 0 Yes No
9 empty 2.05 55.6 19.6 No No
10 empty 2.16 68.4 13.5 No No
4FMX_B 1,8-cineole 2-endo-monooxygenase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 69.8 35.5 Yes No
2 empty 2.4 63.8 37.6 No No
3 empty 2 70.3 21.9 No No
4 empty 1.86 65.6 29.3 No No
5 empty 2.33 66.8 24 No No
6 empty 2.37 65.2 22.6 No No
7 empty 2.19 61.4 20 No No
8 empty 1.91 67.4 15.6 No No
9 empty 2.24 60.4 21.5 No No
10 empty 2.27 65.4 14 No No
4FB2_C 1,8-cineole 2-endo-monooxygenase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.89 69 55.2 Yes Yes
2 bound 2.41 66.3 24.3 No No
3 empty 2.15 69.3 13.3 No No
4 empty 2.42 64.1 20.6 No No
5 empty 2.01 61.9 18.2 No No
6 empty 1.98 68.9 17.5 No No
7 bound 1.79 69.7 16.9 No No
8 empty 2.09 57.9 21.9 No No
9 empty 1.93 74.1 11.1 No No
10 empty 2.24 64.2 11.7 No No
4FB2_D 1,8-cineole 2-endo-monooxygenase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.79 71.7 55.6 Yes Yes
2 empty 2.38 64.8 37.2 No No
3 empty 2.31 66.5 24 No No
4 empty 2.08 69.5 15.3 No No
5 empty 2.04 53.4 15.4 No No
6 empty 2.19 65.9 14.4 No No
7 empty 1.94 63.8 13.3 No No
8 empty 1.96 76.4 9.9 No No
9 empty 2.19 63.3 15.1 No No
10 empty 2.22 62.8 14.6 No No
3BDZ_B 1,8-cineole 2-endo-monooxygenase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.89 69.5 36.7 Yes No
2 empty 2.32 68 35.9 No No
3 empty 2.12 64.4 26.6 No No
4 empty 2.39 62.9 24.2 No No
5 empty 2 67.5 26.5 No No
6 bound 1.5 98.3 0 Yes No
7 empty 2.07 66.6 13.3 No No
8 empty 2.1 59.1 16.9 No No
9 empty 1.85 61.7 12.7 No No
10 empty 2.05 58.6 16.6 No No
4FB2_B 1,8-cineole 2-endo-monooxygenase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.77 72 48.1 Yes Yes
2 empty 2.27 63.7 36.9 No No
3 empty 2.02 57.1 15.4 No No
4 empty 2.39 63.7 14.6 No No
5 bound 2.15 72.6 13.4 No No
6 empty 1.97 60.7 15.1 No No
7 empty 2.27 61.8 13.5 No No
8 empty 2.1 73.4 15.2 No No
9 empty 1.94 68.9 10.7 No No
10 empty 2.14 60 16.4 No No
3BE0_A 1,8-cineole 2-endo-monooxygenase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.91 72.9 27.7 Yes No
2 empty 2.34 68.5 30.3 No No
3 empty 2.04 70.9 19.7 No No
4 empty 2.04 78.3 16.8 No No
5 bound 1.93 98.8 0 Yes No
6 empty 2.22 61.9 16.4 No No
7 empty 2.11 69.5 10.8 No No
8 empty 1.96 67.1 16 No No
9 empty 2.6 65.2 16.9 No No
10 empty 1.83 66.2 14.6 No No
4LHT_A 1,8-cineole 2-endo-monooxygenase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 70.5 28 Yes No
2 empty 2.3 66.7 37.1 No No
3 empty 2.39 65.8 26 No No
4 empty 1.93 70.4 23.4 No No
5 empty 1.92 63.3 23.9 No No
6 empty 2.11 63.6 21.2 No No
7 empty 1.81 68.4 14.8 No No
8 empty 2.22 67.1 22.3 No No
9 empty 2.01 69.1 13.8 No No
10 bound 1.52 99.2 0 Yes No
4L6G_A 1,8-cineole 2-endo-monooxygenase Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.21 68.9 32.4 Yes No
2 empty 2.39 66.2 37.3 No No
3 empty 2.05 66.8 35 No No
4 empty 2.03 69.9 23.5 No No
5 empty 2.31 64.7 27.5 No No
6 empty 2.26 69.1 24.8 No No
7 empty 2.09 55.8 16.4 No No
8 empty 2.32 67.2 15.2 No No
9 bound 1.75 99.2 0 Yes No
10 bound 1.93 64.7 13.2 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed3
Domains assessed as druggable using the strict criteria1
Domains assessed as druggable using the relaxed criteria3

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1T2B_A (3010318) 1,8-cineole 2-endo-monooxygenase Cytochrome P450, Cytochrome P450, UNMATCHED 1.7Å Yes No
3BDZ_A (3310869) 1,8-cineole 2-endo-monooxygenase Cytochrome P450, Cytochrome P450, UNMATCHED 2Å Yes Yes
3BE0_A (3310870) 1,8-cineole 2-endo-monooxygenase Cytochrome P450, Cytochrome P450, UNMATCHED 3.05Å Yes No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score