Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

cinA (Q8VQF6) - Overview - Molecular Target Synopsis

Protein


cinA, 1,8-cineole 2-endo-monooxygenase
Enzyme Classification 1.14.14.133
UniProt Q8VQF6

Also Known as CINA_CITBR, cinA

Involved in the degradation of cineol (eucalyptol). Catalyzes the initial hydroxylation of cineole exclusively at the pro-R carbon to give the (S)-6beta-hydroxycineole. Cineole is the natural substrate of CinA. Homodimer.

4L6G
CRYSTAL STRUCTURE OF P450CIN Y81F MUTANT, CRYSTALLIZED IN 7 MM 1,8- CINEOLE
RCSB/PDB
Inspect Structure
See all 3D Structures for cinA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
404Q8VQF6-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project cinA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For cinA there are:
9 structures (20 chains) solved
9 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis