Molecular Target Synopsis
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Drugs and Clinical Candidates
Druggability
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Dapk2 (Q8VDF3) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed6
Chains with at least one site assessed as druggable using the strict criteria3
Chains with at least one site assessed as druggable using the relaxed criteria6


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2YAB_A Death-associated protein kinase 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.26 67 44.4 Yes Yes
2 empty 2.46 65.4 29.8 No No
3 empty 2.19 65.9 22.6 No No
4 empty 2.54 62.6 26.7 No No
5 empty 2.23 64.8 24 No No
6 empty 2.47 66.2 12.3 No No
7 empty 2.2 63 17.7 No No
8 empty 2.35 62 11.6 No No
9 empty 1.74 55.9 10.8 No No
10 empty 2.4 60.8 11.2 No No
2YA9_B Death-associated protein kinase 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.01 68.1 45.4 Yes Yes
2 empty 2.18 62.3 22.4 No No
3 empty 2.28 59.6 19.3 No No
4 empty 2.28 60.9 20.3 No No
5 empty 2.21 64.7 15.4 No No
6 empty 2.21 52.6 13.6 No No
7 empty 2.4 56.1 18.4 No No
8 empty 1.52 52.7 18.1 No No
9 empty 1.98 63.5 11.7 No No
10 empty 2.31 60 11.8 No No
2YAA_A Death-associated protein kinase 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.96 65.9 44.8 Yes No
2 empty 2.3 63.7 28.6 No No
3 empty 2.33 64.3 19.1 No No
4 empty 2.5 70.3 19.6 No No
5 empty 2.42 64.1 15.3 No No
6 empty 2.23 63.8 17.3 No No
7 empty 1.59 63.8 11.3 No No
8 empty 1.81 53 10.6 No No
9 empty 2.28 61.9 8.1 No No
10 empty 1.85 51.6 9 No No
2YAA_B Death-associated protein kinase 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.88 71.3 45.3 Yes Yes
2 empty 2.46 63.7 30 No No
3 empty 2.24 68.1 25 No No
4 empty 2.69 63.7 23.9 No No
5 empty 1.86 61.7 25.9 No No
6 empty 2.3 64.4 18.6 No No
7 empty 2.25 66.2 16.4 No No
8 empty 2.2 56.8 19 No No
9 empty 2.71 72.7 13 No No
10 empty 1.75 65.6 10.6 No No
2YAB_B Death-associated protein kinase 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.25 64.9 29 Yes No
2 bound 2.1 67.6 26.4 No No
3 empty 2.32 60.7 18.7 No No
4 empty 2.17 62.7 25 No No
5 empty 1.52 52.9 17.8 No No
6 empty 2.22 57 13.8 No No
7 empty 2.34 54.8 13.3 No No
8 empty 1.92 53.8 12.3 No No
9 empty 2.24 55.3 11.7 No No
10 empty 2.21 62.3 13.1 No No
2YA9_A Death-associated protein kinase 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 66 45.7 Yes No
2 empty 2.32 65.1 25.3 No No
3 empty 2.22 58.9 18.7 No No
4 empty 2.31 61.1 18.3 No No
5 empty 2.26 65.4 18.9 No No
6 empty 2.33 53.9 13.2 No No
7 empty 2.12 64.9 13.7 No No
8 empty 2.26 59.1 13.2 No No
9 empty 2.27 51.7 10.7 No No
10 empty 1.86 73 9 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed3
Domains assessed as druggable using the strict criteria3
Domains assessed as druggable using the relaxed criteria3

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2YA9_A (4029892) Death-associated protein kinase 2 Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit (Homo Multimer) 2.3Å Yes Yes
2YA9_B (4029892) Death-associated protein kinase 2 Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit (Homo Multimer) 2.3Å Yes Yes
2YAA_B (4268145) Death-associated protein kinase 2 Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit (Homo Multimer) 2.3Å Yes Yes
2YAA_A (4268145) Death-associated protein kinase 2 Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit (Homo Multimer) 2.3Å Yes Yes
2YAB_A (4085305) Death-associated protein kinase 2 Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit (Homo Multimer) 1.9Å Yes Yes
2YAB_B (4085305) Death-associated protein kinase 2 Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit (Homo Multimer) 1.9Å Yes Yes
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score