Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Dapk2 (Q8VDF3) - Overview - Molecular Target Synopsis

Protein


Dapk2, Death-associated protein kinase 2
Enzyme Classification 2.7.11.1
UniProt Q8VDF3

Also Known as DAPK2_MOUSE, Dapk2

Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell death signals. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (By similarity). Regulates granulocytes motility by controlling cell spreading and polarization (PubMed:24163421). Homodimer in its autoinhibited state. Active as monomer. Interacts with 14-3-3 proteins YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ and SFN; the interaction requires DAPK2 phosphorylation at Thr-369 and suppresses DAPK2 kinase activity and DAPK2-induced apoptosis.

2YA9
CRYSTAL STRUCTURE OF THE AUTOINHIBITED FORM OF MOUSE DAPK2
RCSB/PDB
Inspect Structure
See all 3D Structures for Dapk2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
489Q8VDF3-2
370Q8VDF3-1

Sub-cellular localization


UniProt: Dapk2 is active in the following subcellular-locations: autophagosome lumen, cytoplasm, cytoplasmic vesicle.
GO terms: Dapk2 is active in the following subcellular-locations: autophagosome lumen, cytoplasm, cytoplasmic vesicle, Golgi apparatus, intracellular membrane-bounded organelle, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Dapk2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Dapk2 there are:
3 structures (6 chains) solved
3 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

Dapk2 is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (2YAB_A, 2YAB_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Dapk2 has been screened with compounds ( bioactivities). (see details)