Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
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Chemistry
Ligand Efficiency Plot
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mre11 (Q8U1N9) - Overview - Molecular Target Synopsis

Protein


mre11, DNA double-strand break repair protein Mre11
Enzyme Classification 3.1.-.-
UniProt Q8U1N9

Also Known as MRE11_PYRFU, mre11

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair (PubMed:11029422, PubMed:18854158, PubMed:18957200). The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA (PubMed:18957200). Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity (PubMed:11029422, PubMed:18854158, PubMed:18957200). Homodimer (PubMed:18854158). Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits (PubMed:11371344, PubMed:21441914, PubMed:22102415). Homodimerization facilitates DNA binding (PubMed:18854158).

4HD0
MRE11 ATLD17/18 MUTATION RETAINS TEL1/ATM ACTIVITY BUT BLOCKS DNA DOUBLE-STRAND BREAK REPAIR
RCSB/PDB
Inspect Structure
See all 3D Structures for mre11

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
426Q8U1N9-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project mre11 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For mre11 there are:
8 structures (12 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis