Molecular Target Synopsis
Overview
Domains and Structures
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Ligand Efficiency Plot
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srp54 (Q8U070) - Overview - Molecular Target Synopsis

Protein


srp54, Signal recognition particle 54 kDa protein
UniProt Q8U070

Also Known as SRP54_PYRFU, srp54

Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19 (Probable).

3DM5
STRUCTURES OF SRP54 AND SRP19, THE TWO PROTEINS ASSEMBLING THE RIBONUCLEIC CORE OF THE SIGNAL RECOGNITION PARTICLE FROM THE ARCHAEON PYROCOCCUS FURIOSUS.
RCSB/PDB
Inspect Structure
See all 3D Structures for srp54

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
443Q8U070-1

Sub-cellular localization


UniProt: srp54 is active in the following subcellular-locations: cytoplasm.
GO terms: srp54 is active in the following subcellular-locations: signal recognition particle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project srp54 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For srp54 there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis