Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC16A10 (Q8TF71) - Overview - Molecular Target Synopsis

Protein


SLC16A10, Monocarboxylate transporter 10
UniProt Q8TF71

Also Known as MOT10_HUMAN, SLC16A10, MCT10, TAT1

Sodium-independent transporter that mediates the uptake of aromatic acids. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLC16A10 is active in the following subcellular-locations: basolateral cell membrane, cell membrane.
GO terms: SLC16A10 is active in the following subcellular-locations: basolateral plasma membrane, integral component of plasma membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC16A10 has gain in 0 cell-lines, loss in 4 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RPMI_8226, IGROV1, MOLT_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: RPMI 8226, MOLP-8, NCI-H2106

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)


Screening and Chemistry


SLC16A10 has been screened with compounds ( bioactivities). (see details)