Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC37A2 (Q8TED4) - Overview - Molecular Target Synopsis

Protein


SLC37A2, Glucose-6-phosphate exchanger SLC37A2
UniProt Q8TED4

Also Known as G6PT3_HUMAN, SLC37A2

Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLC37A2 is active in the following subcellular-locations: endoplasmic reticulum membrane.
GO terms: SLC37A2 is active in the following subcellular-locations: endoplasmic reticulum membrane, extracellular exosome, integral component of endoplasmic reticulum membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC37A2 has gain in 0 cell-lines, loss in 6 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MDA_MB_231, HOP_92, SK_MEL_28

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: RPMI-7951, HCC193, PK-45P

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, GM12878, SK-N-SH

(see details)