Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TBCK (Q8TEA7) - Overview - Molecular Target Synopsis

Protein


TBCK, TBC domain-containing protein kinase-like protein
UniProt Q8TEA7

Also Known as TBCK_HUMAN, TBCK, TBCKL

Involved in the modulation of mTOR signaling and expression of mTOR complex components (PubMed:27040691, PubMed:23977024). Involved in the regulation of cell proliferation and growth (PubMed:23977024, PubMed:24576458). Involved in the control of actin-cytoskeleton organization (PubMed:23977024).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TBCK is active in the following subcellular-locations: cytoplasm, cytoskeleton, midbody, spindle.
GO terms: TBCK is active in the following subcellular-locations: cytoplasm, midbody, mitotic spindle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TBCK has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC2688, NCI-H209, SK-OV-3

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, BJ

(see details)

RNA Interference


TBCK was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: SCC90, TE6. (see details)


Screening and Chemistry


TBCK has been screened with compounds ( bioactivities). (see details)