Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NSUN6 (Q8TEA1) - Overview - Molecular Target Synopsis

Protein


NSUN6, Putative methyltransferase NSUN6
Enzyme Classification 2.1.1.-
UniProt Q8TEA1

Also Known as NSUN6_HUMAN, NSUN6, NOPD1

May have S-adenosyl-L-methionine-dependent methyl-transferase activity.

5WWQ
CRYSTAL STRUCTURE OF HUMAN NSUN6
RCSB/PDB
Inspect Structure
See all 3D Structures for NSUN6

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
469ENSG00000241058ENST00000377304ENSP00000366519Q8TEA1-1

Sub-cellular localization


GO terms: NSUN6 is active in the following subcellular-locations: cytoplasm, cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NSUN6 has gain in 3 cell-lines, loss in 6 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, CCRF_CEM, MOLT_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DMS 53, SU-DHL-1, KYSE-150

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, SK-N-SH, GM12878

(see details)

3D Structures


For NSUN6 there are:
4 structures (8 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis