PXYLP1 (Q8TE99) - Overview - Molecular Target Synopsis
PXYLP1, 2-phosphoxylose phosphatase 1
Enzyme Classification 3.1.3.-
Also Known as PXYP1_HUMAN, PXYLP1, ACPL2, HEL124, XYLP
Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains. Interacts with B3GAT3; the interaction increases the 2-phosphoxylose phosphatase activity of PXYLP1 during completion of linkage region formation in a B3GAT3-mediated manner.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|480||ENSG00000155893||ENST00000286353, ENST00000393010||ENSP00000286353, ENSP00000376733||Q8TE99-1|
UniProt: PXYLP1 is active in the following subcellular-locations: golgi apparatus membrane.
GO terms: PXYLP1 is active in the following subcellular-locations: Golgi apparatus, Golgi membrane, integral component of membrane.