Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACTRT2 (Q8TDY3) - Overview - Molecular Target Synopsis

Protein


ACTRT2, Actin-related protein T2
UniProt Q8TDY3

Also Known as ACTT2_HUMAN, ACTRT2, ARPM2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
403ENSG00000169717ENST00000378404ENSP00000367658
377Q8TDY3-1

Sub-cellular localization


UniProt: ACTRT2 is active in the following subcellular-locations: cytoplasm, cytoskeleton.
GO terms: ACTRT2 is active in the following subcellular-locations: cytoplasm, cytoskeleton.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACTRT2 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: CAKI_1, HCC_2998, HCT_15

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to ACTRT2 there are:
80 structures (246 chains) solved
69 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ACTRT2 has been screened with compounds ( bioactivities). (see details)