Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

NEK7 (Q8TDX7) - Overview - Molecular Target Synopsis


NEK7, Serine/threonine-protein kinase Nek7
Enzyme Classification
UniProt Q8TDX7

Also Known as NEK7_HUMAN, NEK7

Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1. Monomer. Interacts with NEK9.

Inspect Structure
See all 3D Structures for NEK7

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: NEK7 is active in the following subcellular-locations: centrosome, cytoplasm, cytoskeleton, microtubule organizing center, nucleus, spindle pole.
GO terms: NEK7 is active in the following subcellular-locations: cytoplasm, microtubule, microtubule organizing center, nucleoplasm, spindle pole.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project NEK7 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: HS578T, SF_268, NCI_H226

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H2373, A172, NCI-H2804

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: BJ, NHLF, SK-N-SH

(see details)

RNA Interference

NEK7 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: PEO14, H2342. (see details)

3D Structures

For NEK7 there are:
4 structures (8 chains) solved
2 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

NEK7 has been screened with 729 compounds (1358 bioactivities), 3 compounds have bioactivities that show binding affinity of <= 500nM (3 bioactivities). (see details)