ACMSD (Q8TDX5) - Overview - Molecular Target Synopsis
ACMSD, 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Enzyme Classification 22.214.171.124
Also Known as ACMSD_HUMAN, ACMSD
Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. Monomer.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|278||ENSG00000153086||ENST00000283054, ENST00000392928||ENSP00000283054, ENSP00000376659||Q8TDX5-2|
GO terms: ACMSD is active in the following subcellular-locations: cytoplasm, cytosol.