Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACMSD (Q8TDX5) - Overview - Molecular Target Synopsis

Protein


ACMSD, 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Enzyme Classification 4.1.1.45
UniProt Q8TDX5

Also Known as ACMSD_HUMAN, ACMSD

Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. Monomer.

4OFC
2.0 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF HUMAN 2-AMINO-3- CARBOXYMUCONATE-6-SEMIALDEHYE DECARBOXYLASE
RCSB/PDB
Inspect Structure
See all 3D Structures for ACMSD

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
336ENSG00000153086ENST00000356140ENSP00000348459Q8TDX5-1
278ENSG00000153086ENST00000283054, ENST00000392928ENSP00000283054, ENSP00000376659Q8TDX5-2

Sub-cellular localization


GO terms: ACMSD is active in the following subcellular-locations: cytoplasm, cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACMSD has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SN12C, HL_60, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1395, Hs 746T, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For ACMSD there are:
5 structures (25 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis