Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

STK35 (Q8TDR2) - Overview - Molecular Target Synopsis

Protein


STK35, Serine/threonine-protein kinase 35
Enzyme Classification 2.7.11.1
UniProt Q8TDR2

Also Known as STK35_HUMAN, STK35, CLIK1, PDIK1, STK35L1

Interacts with PDLIM1/CLP-36.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: STK35 is active in the following subcellular-locations: cytoplasm, nucleolus, nucleus.
GO terms: STK35 is active in the following subcellular-locations: cytoplasm, nuclear body, nucleolus, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project STK35 has gain in 3 cell-lines, loss in 3 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HOP_62, COLO205, SW_620

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DMS 454, LS1034, HCC38

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HMEC, IMR-90

(see details)

RNA Interference


STK35 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MDAMB231, COV362. (see details)

3D Structures


At greater than 35% identity similarity to STK35 there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

STK35 is solved in complex with the approved drug(s):

DB8/BOSUTINIB (6FDY_U).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


STK35 has been screened with 85 compounds (92 bioactivities), 12 compounds have bioactivities that show binding affinity of <= 500nM (12 bioactivities). (see details)