Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACTRT1 (Q8TDG2) - Overview - Molecular Target Synopsis

Protein


ACTRT1, Actin-related protein T1
UniProt Q8TDG2

Also Known as ACTT1_HUMAN, ACTRT1, ARPT1

Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
418ENSG00000123165ENST00000371124ENSP00000360165
376Q8TDG2-1

Sub-cellular localization


UniProt: ACTRT1 is active in the following subcellular-locations: cytoplasm, cytoskeleton, nucleus.
GO terms: ACTRT1 is active in the following subcellular-locations: cytoplasm, cytoskeleton, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACTRT1 has gain in 0 cell-lines, loss in 33 cell-lines and no signal in 972 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to ACTRT1 there are:
81 structures (246 chains) solved
70 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ACTRT1 has been screened with compounds ( bioactivities). (see details)