Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MYOZ3 (Q8TDC0) - Overview - Molecular Target Synopsis

Protein


MYOZ3, Myozenin-3
UniProt Q8TDC0

Also Known as MYOZ3_HUMAN, MYOZ3, FRP3

Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. Interacts with ACTN2, LDB3, FLNC, PPP3CA and TCAP.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MYOZ3 is active in the following subcellular-locations: cytoplasm, myofibril, sarcomere, z line.
GO terms: MYOZ3 is active in the following subcellular-locations: actin cytoskeleton, Z disc.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MYOZ3 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: A498, HL_60, MCF7

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC1319, Hs 746T, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)