Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC2A14 (Q8TDB8) - Overview - Molecular Target Synopsis

Protein


SLC2A14, Solute carrier family 2, facilitated glucose transporter member 14
UniProt Q8TDB8

Also Known as GTR14_HUMAN, SLC2A14, GLUT14, GLUT3

Facilitative glucose transporter (By similarity). May have a specific function related to spermatogenesis.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLC2A14 is active in the following subcellular-locations: membrane.
GO terms: SLC2A14 is active in the following subcellular-locations: integral component of membrane, nucleus, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC2A14 has gain in 6 cell-lines, loss in 1 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCI-M2, C2BBe1, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 90% identity similarity to SLC2A14 there are:
4 structures (6 chains) solved
4 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

SLC2A14 is solved in complex with the approved drug(s):

BGC/DEXTROSE (4ZW9_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SLC2A14 has been screened with compounds ( bioactivities). (see details)