TRPM4 (Q8TD43) - Overview - Molecular Target Synopsis
TRPM4, Transient receptor potential cation channel subfamily M member 4
Also Known as TRPM4_HUMAN, TRPM4, LTRPC4
Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization (PubMed:12015988, PubMed:29211723). While it is activated by increase in intracellular Ca(2+), it is impermeable to it (PubMed:12015988). Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Homotetramer.
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UniProt: TRPM4 is active in the following subcellular-locations: cell membrane, endoplasmic reticulum, golgi apparatus.
GO terms: TRPM4 is active in the following subcellular-locations: cytosol, endoplasmic reticulum, Golgi apparatus, neuronal cell body, nucleoplasm, plasma membrane, sodium channel complex, spanning component of membrane, spanning component of plasma membrane.