Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

TRPM4 (Q8TD43) - Overview - Molecular Target Synopsis


TRPM4, Transient receptor potential cation channel subfamily M member 4
UniProt Q8TD43

Also Known as TRPM4_HUMAN, TRPM4, LTRPC4

Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization (PubMed:12015988, PubMed:29211723). While it is activated by increase in intracellular Ca(2+), it is impermeable to it (PubMed:12015988). Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Homotetramer.

Inspect Structure
See all 3D Structures for TRPM4

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: TRPM4 is active in the following subcellular-locations: cell membrane, endoplasmic reticulum, golgi apparatus.
GO terms: TRPM4 is active in the following subcellular-locations: cytosol, endoplasmic reticulum, Golgi apparatus, neuronal cell body, nucleoplasm, plasma membrane, sodium channel complex, spanning component of membrane, spanning component of plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project TRPM4 has gain in 2 cell-lines, loss in 2 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: HL_60, SR, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1781, NCI-H2126, HCC1263

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, HUVEC

(see details)

3D Structures

For TRPM4 there are:
4 structures (16 chains) solved
4 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

TRPM4 has been screened with 1 compounds (1 bioactivities). (see details)