Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC2A12 (Q8TD20) - Overview - Molecular Target Synopsis

Protein


SLC2A12, Solute carrier family 2, facilitated glucose transporter member 12
UniProt Q8TD20

Also Known as GTR12_HUMAN, SLC2A12, GLUT12, GLUT8

Facilitative glucose transporter.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
617ENSG00000146411ENST00000275230ENSP00000275230Q8TD20-1

Sub-cellular localization


UniProt: SLC2A12 is active in the following subcellular-locations: cytoplasm, endomembrane system, perinuclear region.
GO terms: SLC2A12 is active in the following subcellular-locations: endomembrane system, integral component of plasma membrane, perinuclear region of cytoplasm, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC2A12 has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, OVCAR_3, NCI_H322M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: G122, NCI-H345, OAW28

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: AG445, SK-N-SH, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to SLC2A12 there are:
7 structures (11 chains) solved
3 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

SLC2A12 is solved in complex with the approved drug(s):

BGC/DEXTROSE (4GBZ_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SLC2A12 has been screened with compounds ( bioactivities). (see details)