Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

SLC2A12 (Q8TD20) - Overview - Molecular Target Synopsis


SLC2A12, Solute carrier family 2, facilitated glucose transporter member 12
UniProt Q8TD20

Also Known as GTR12_HUMAN, SLC2A12, GLUT12, GLUT8

Facilitative glucose transporter.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: SLC2A12 is active in the following subcellular-locations: cytoplasm, endomembrane system, perinuclear region.
GO terms: SLC2A12 is active in the following subcellular-locations: endomembrane system, integral component of plasma membrane, perinuclear region of cytoplasm, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project SLC2A12 has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: COLO205, OVCAR_3, NCI_H322M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: G122, NCI-H345, OAW28

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: AG445, SK-N-SH, HSMM

(see details)

3D Structures

At greater than 35% identity similarity to SLC2A12 there are:
7 structures (11 chains) solved
3 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

SLC2A12 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

SLC2A12 has been screened with compounds ( bioactivities). (see details)