Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AGR3 (Q8TD06) - Overview - Molecular Target Synopsis

Protein


AGR3, Anterior gradient protein 3
UniProt Q8TD06

Also Known as AGR3_HUMAN, AGR3, BCMP11, PDIA18

Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells. Interacts with LYPD3 and DAG1 (alphaDAG1).

3PH9
CRYSTAL STRUCTURE OF THE HUMAN ANTERIOR GRADIENT PROTEIN 3
RCSB/PDB
Inspect Structure
See all 3D Structures for AGR3

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: AGR3 is active in the following subcellular-locations: endoplasmic reticulum.
GO terms: AGR3 is active in the following subcellular-locations: endoplasmic reticulum, intracellular membrane-bounded organelle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project AGR3 has gain in 16 cell-lines, loss in 2 cell-lines and no signal in 987 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: T47D, KM12, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MKN-45, Okajima, GTL-16

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: MCF-7, SK-N-SH, NHLF

(see details)

3D Structures


For AGR3 there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis