MRAP (Q8TCY5) - Overview - Molecular Target Synopsis
MRAP, Melanocortin-2 receptor accessory protein
Also Known as MRAP_HUMAN, MRAP, C21orf61, FALP
Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells. Homodimer and heterodimer. Forms antiparallel homodimers and heterodimers with MRAP2. Interacts with MC1R, MC2R, MC3R, MC4R and MC5R.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|172||ENSG00000170262||ENST00000399784, ENST00000303645||ENSP00000382684, ENSP00000306697||Q8TCY5-1|
|102||ENSG00000170262||ENST00000339944, ENST00000399786||ENSP00000343661, ENSP00000382686||Q8TCY5-2|
UniProt: MRAP is active in the following subcellular-locations: cell membrane, endoplasmic reticulum membrane.
GO terms: MRAP is active in the following subcellular-locations: endoplasmic reticulum, endoplasmic reticulum membrane, integral component of membrane, plasma membrane.