Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation

GRIN3A (Q8TCU5) - Overview - Molecular Target Synopsis


GRIN3A, Glutamate receptor ionotropic, NMDA 3A
UniProt Q8TCU5

Also Known as NMD3A_HUMAN, GRIN3A, KIAA1973

NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism. Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex with GRIN1, GRIN2A or GRIN2B and PPP2CB. Probably interacts with PPP2CB. No complex with PPP2CB is detected when NMDARs are stimulated by NMDA.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform


GRIN3A is targeted by Approved Drug Esketamine. (see details)

Sub-cellular localization

UniProt: GRIN3A is active in the following subcellular-locations: cell junction, cell membrane, postsynaptic cell membrane, postsynaptic density, synapse.
GO terms: GRIN3A is active in the following subcellular-locations: cell junction, integral component of membrane, membrane, neuron projection, neuronal cell body, NMDA selective glutamate receptor complex, postsynaptic density, postsynaptic membrane, synapse.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project GRIN3A has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: ACHN, HS578T, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H810, HGC-27, NCI-H510A

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference

GRIN3A was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

Screening and Chemistry

GRIN3A has been screened with 459 compounds (705 bioactivities), 165 compounds have bioactivities that show binding affinity of <= 500nM (199 bioactivities). (see details)