Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNA Interference
Mutations

GRIN3A (Q8TCU5) - Overview - Molecular Target Synopsis



Protein


GRIN3A, Glutamate receptor ionotropic, NMDA 3A
UniProt Q8TCU5

Also Known as NMD3A_HUMAN, GRIN3A, KIAA1973

NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism. Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex with GRIN1, GRIN2A or GRIN2B and PPP2CB. Probably interacts with PPP2CB. No complex with PPP2CB is detected when NMDARs are stimulated by NMDA.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1115ENSG00000198785ENST00000361820ENSP00000355155Q8TCU5-1

Sub-cellular localization


UniProt: GRIN3A is active in the following subcellular-locations: Cell junction, Cell membrane, postsynaptic cell membrane, postsynaptic density, synapse.
GO terms: GRIN3A is active in the following subcellular-locations: cell junction, dendrite, integral component of membrane, membrane, neuron projection, neuronal cell body, NMDA selective glutamate receptor complex, plasma membrane, postsynaptic density, postsynaptic membrane, synapse.



UniProt
GO terms

Mutations in Cancer


Please click the link to see mutations reported in COSMIC - Cell Lines Project
Please click the link to see mutations reported in COSMIC
Please click the link to see mutations reported in Cancer Gene Census
Please click the link to see mutations reported in ICGC
(see details)

Gene Expression


In NCI60, the highest expressing cell lines are: ACHN, HS578T, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H810, HGC-27, NCI-H510A

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


GRIN3A was reported in the following RNAI studies:

AACR Journals - Results of primary druggable genome v2 (DG2) Achilles heel siRNA screen in KMS11 multiple myeloma cells, the highest RNAi cell lines are: KMS11. (see details)


Screening and Chemistry


GRIN3A has been screened with 459 compounds (705 bioactivities), 165 compounds have bioactivities that show binding affinity of <= 500nM (199 bioactivities). (see details)