Molecular Target
Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Cellline Data Matrix
Gene Expression
Gene Copy Number Variation
RNA Interference
Mutations

Molecular Target Synopsis - GRIN3A (Q8TCU5) - Overview

Protein


GRIN3A, Glutamate receptor ionotropic, NMDA 3A
UniProt Q8TCU5

Also Known as NMD3A_HUMAN, GRIN3A, KIAA1973

NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism. Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex with GRIN1, GRIN2A or GRIN2B and PPP2CB. Probably interacts with PPP2CB. No complex with PPP2CB is detected when NMDARs are stimulated by NMDA.

Sub-cellular localization


UniProt: GRIN3A is active in the following subcellular-locations: Cell junction, Cell membrane, Postsynaptic cell membrane, Postsynaptic density, Synapse.



UniProt
GO terms

Mutations in Cancer


Please click the link to see mutations reported in Cancer Gene Census

Please click the link to see mutations reported in ICGC

According to the Cosmic, GRIN3A has 6 reported mutations in cell lines ....p.Q469Q (1), p.A195V (1), p.G494E (1), p.L673H (1), p.R96C (1), p.E205K (1)

The mutation data was obtained from the Sanger Institute Catalogue Of Somatic Mutations In Cancer web site, http://www.sanger.ac.uk/cosmic
Bamford et al (2004) The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website. Br J Cancer, 91,355-358.
Please click the link to see mutations reported in MoKCa

(see details)

Gene Copy Number Variation


GRIN3A has an absolute copy number > 7 in 1 cell lines, the highest copy numbers are in cell lines : NCIH2009. (see details)

Gene Expression


In the NCI - NCI 60 Reference panel, the highest expressing cell lines are: HCT116, OVCAR8. (see details)

RNA Interference


GRIN3A was reported in the following RNAI studies:

AACR Journals - Results of primary druggable genome v2 (DG2) Achilles heel siRNA screen in KMS11 multiple myeloma cells, the highest RNAi cell lines are: KMS11. (see details)


Screening and Chemistry


GRIN3A has been screened with 458 compounds (705 bioactivities), 165 compounds have bioactivities that show binding affinity of <= 500nM (198 bioactivities). (see details)