GRIN3A (Q8TCU5) - Overview - Molecular Target Synopsis
GRIN3A, Glutamate receptor ionotropic, NMDA 3A
Also Known as NMD3A_HUMAN, GRIN3A, KIAA1973
NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism. Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex with GRIN1, GRIN2A or GRIN2B and PPP2CB. Probably interacts with PPP2CB. No complex with PPP2CB is detected when NMDARs are stimulated by NMDA.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
UniProt: GRIN3A is active in the following subcellular-locations: Cell junction, Cell membrane, postsynaptic cell membrane, postsynaptic density, synapse.
GO terms: GRIN3A is active in the following subcellular-locations: cell junction, dendrite, integral component of membrane, membrane, neuron projection, neuronal cell body, NMDA selective glutamate receptor complex, plasma membrane, postsynaptic density, postsynaptic membrane, synapse.
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