GRIN3A, Glutamate receptor ionotropic, NMDA 3A
Also Known as
NMD3A_HUMAN, GRIN3A, KIAA1973
NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism. Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex with GRIN1, GRIN2A or GRIN2B and PPP2CB. Probably interacts with PPP2CB. No complex with PPP2CB is detected when NMDARs are stimulated by NMDA.
UniProt: GRIN3A is active in the following subcellular-locations: Cell junction, Cell membrane, Postsynaptic cell membrane, Postsynaptic density, Synapse.
Mutations in Cancer
|Please click the link to see mutations reported in Cancer Gene Census|
|Please click the link to see mutations reported in ICGC|
|According to the Cosmic, GRIN3A has 6 reported mutations in cell lines ....p.Q469Q (1), p.A195V (1), p.G494E (1), p.L673H (1), p.R96C (1), p.E205K (1)|
The mutation data was obtained from the Sanger Institute Catalogue Of Somatic Mutations In Cancer web site, http://www.sanger.ac.uk/cosmic
Bamford et al (2004) The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website. Br J Cancer, 91,355-358.
|Please click the link to see mutations reported in MoKCa|
Gene Copy Number Variation
GRIN3A has an absolute copy number > 7 in 1 cell lines, the highest copy numbers are in cell lines : NCIH2009. (see details)
In the NCI - NCI 60 Reference panel, the highest expressing cell lines are: HCT116, OVCAR8. (see details)
GRIN3A was reported in the following RNAI studies:
AACR Journals - Results of primary druggable genome v2 (DG2) Achilles heel siRNA screen in KMS11 multiple myeloma cells, the highest RNAi cell lines are: KMS11. (see details)
Screening and Chemistry
GRIN3A has been screened with 458 compounds (705 bioactivities), 165 compounds have bioactivities that show binding affinity of <= 500nM (198 bioactivities). (see details)