Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC7A13 (Q8TCU3) - Overview - Molecular Target Synopsis

Protein


SLC7A13, Solute carrier family 7 member 13
UniProt Q8TCU3

Also Known as S7A13_HUMAN, SLC7A13, AGT1, XAT2

Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
470ENSG00000164893ENST00000297524ENSP00000297524Q8TCU3-1
433ENSG00000164893ENST00000419776ENSP00000410982Q8TCU3-2

Sub-cellular localization


UniProt: SLC7A13 is active in the following subcellular-locations: membrane.
GO terms: SLC7A13 is active in the following subcellular-locations: integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC7A13 has gain in 14 cell-lines, loss in 3 cell-lines and no signal in 988 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, OVCAR_8, ACHN

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)