Molecular Target Synopsis
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NT5C (Q8TCD5) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 07/05/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 07/05/2019)


Chains assessed8
Chains with at least one site assessed as druggable using the strict criteria1
Chains with at least one site assessed as druggable using the relaxed criteria8


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4YIH_B 5'(3')-deoxyribonucleotidase, cytosolic type Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.63 72.9 27.2 Yes No
2 empty 2.34 62.3 24.8 No No
3 empty 1.83 68.8 11.5 No No
4 empty 1.47 73.7 11.4 No No
5 empty 2.81 69.6 8.7 No No
6 empty 2.2 60 11 No No
7 empty 2.1 67.3 8 No No
8 empty 2.96 76.2 6.5 No No
9 empty 2.89 59.6 6.9 No No
10 empty 1.54 61.2 8.7 No No
2I7D_A 5'(3')-deoxyribonucleotidase, cytosolic type Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.66 76.2 25.7 Yes No
2 empty 2.3 63.1 25.6 No No
3 empty 2.07 70.9 27.2 No No
4 empty 2.11 74.9 14.1 No No
5 empty 2.64 64.7 14.9 No No
6 empty 2.87 62.3 22.2 No No
7 empty 2.12 63.1 12.9 No No
8 empty 2.52 65.9 7.9 No No
9 empty 2.36 74.1 12.4 No No
10 empty 2.51 59.4 8.6 No No
6G2N_A 5'(3')-deoxyribonucleotidase, cytosolic type Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.63 70.7 32.9 Yes No
2 empty 2.1 61.1 27.8 No No
3 empty 1.93 66.2 15.2 No No
4 empty 1.79 65 24 No No
5 empty 2.67 66.2 8.8 No No
6 empty 2.92 66.5 9.6 No No
7 empty 2.69 63.5 7.6 No No
8 empty 2.12 63.4 11.1 No No
9 empty 1.85 61.8 9.1 No No
10 empty 2.73 72.1 8.4 No No
4L57_A 5'(3')-deoxyribonucleotidase, cytosolic type Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.66 72.1 27.2 Yes No
2 empty 2.45 63.4 24.1 No No
3 empty 1.87 71.4 12.5 No No
4 empty 2.12 68.7 17.4 No No
5 empty 2.72 63.4 14.2 No No
6 bound 2.84 67.8 12 No No
7 empty 2.05 62.9 8.6 No No
8 empty 2.26 65 11.3 No No
9 empty 2.52 62.1 8.4 No No
10 empty 2.79 69.1 9.3 No No
4YIH_A 5'(3')-deoxyribonucleotidase, cytosolic type Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.73 77.1 21 Yes No
2 empty 2.03 67.1 23.1 No No
3 empty 2.1 61.8 19 No No
4 empty 2.25 65.2 12.8 No No
5 empty 2.2 74.4 12.2 No No
6 empty 2.15 61.9 9.9 No No
7 empty 2.84 73.8 7.4 No No
8 empty 2.09 67.1 7.5 No No
9 empty 2.74 57.3 10.1 No No
10 empty 1.92 62.5 7.2 No No
2I7D_B 5'(3')-deoxyribonucleotidase, cytosolic type Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.65 80.2 21.2 Yes Yes
2 empty 2.37 61 22.9 No No
3 empty 2.19 72.7 13.4 No No
4 empty 2.44 75.4 11.6 No No
5 empty 2.74 66.5 18 No No
6 empty 2.05 61.5 11.5 No No
7 empty 2.71 66.3 10.9 No No
8 empty 2.15 60.9 14.5 No No
9 empty 1.89 61.1 7.7 No No
10 empty 1.71 55.4 9.5 No No
4L57_B 5'(3')-deoxyribonucleotidase, cytosolic type Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.62 71.6 29.4 Yes No
2 empty 2.3 58 27.6 No No
3 empty 1.85 65.2 13.8 No No
4 empty 2.35 79.4 11.4 No No
5 empty 2.66 67.2 9.1 No No
6 empty 2.71 71.7 6.6 No No
7 empty 2.15 57.1 14.4 No No
8 empty 2.45 58 11.3 No No
9 empty 1.5 62.6 8.1 No No
10 empty 2.05 75 9.1 No No
6G2N_B 5'(3')-deoxyribonucleotidase, cytosolic type Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.62 76.6 23.5 Yes No
2 empty 2.12 61.5 22.4 No No
3 empty 1.37 71.5 12.6 No No
4 empty 2.04 69.3 11.1 No No
5 empty 2.76 67.3 8.5 No No
6 empty 2.09 58.3 13.1 No No
7 empty 2.68 62.1 11.3 No No
8 empty 1.48 64 9.1 No No
9 empty 1.52 66.9 8.3 No No
10 empty 2.02 52 10.7 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed2
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria2

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2I7D_A (3120013) 5'(3')-deoxyribonucleotidase, cytosolic type HAD-like, HAD-like, 5 (3 )-deoxyribonucleotidase (dNT-2) 1.2Å Yes No
2I7D_A (4197425) 5'(3')-deoxyribonucleotidase, cytosolic type HAD-like, HAD-like, 5 (3 )-deoxyribonucleotidase (dNT-2) (Homo Multimer) 1.2Å Yes No
2I7D_B (4197425) 5'(3')-deoxyribonucleotidase, cytosolic type HAD-like, HAD-like, 5 (3 )-deoxyribonucleotidase (dNT-2) (Homo Multimer) 1.2Å Yes No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score